Endocrine Abstracts

Introduction: About 3% of patients treated with amiodarone develop thyrotoxicosis (amiodarone induced thyrotoxicosis, AIT). Steroids and carbimazole are the main treatment options with surgical thyroidectomy performed in resistant cases. Radioiodine is believed to be unhelpful based on presumed poor radioiodine uptake by thyroid tissue saturated with iodine. We present a case of AIT with a low technetium uptake being successfully treated with radioiodine ablation.<p class=...

Background: The hypothalamic neuropeptides kisspeptin and neurokinin B (NKB) are both obligate for normal gonadotrophin secretion. Studies in patients with loss-of-function mutations in NKB signalling suggest that kisspeptin is functionally upstream of NKB, but this hierarchy is unexplored in healthy men and women. We hypothesised that kisspeptin augmentation of estrogen-induced mid-cycle LH secretion will not be abrogated by pharmacological blockade of NKB.<p class="abste...

Background: Radioiodine ablation is an effective curative treatment for hyperthyroidism in virtually all patients with single or multiple doses. The dosage of radioiodine used in the treatment of thyrotoxicosis has varied widely according to local experience and practice. Administration of low doses could lead to inadequate or delayed response, while using larger doses is associated with the risk of increased incidence of hypothyroidism.Introduction: In ...

The development and maturation of kisspeptin neurons is critical for activating GnRH release needed to initiate puberty. However, little is known of the development and organization of kisspeptin neurons in the human hypothalamus and the anatomical architecture of kisspeptin neurons in rodents is distinct from that of primates.The aim of the present study was to examine the development of the hypothalamic neuroendocrine circuitry that sets the structural...

Context: Respiratory failure as a component of severe hypothyroidism has high mortality and a number of pathological mechanisms have been proposed. These range from cerebral causes to neuromuscualr and pulmonary factors. Changes due to mucopolysacharide deposition in the lungs is another postulated mechanism, but radiological changes are hitherto not clinically demonstrated.Objective: A case of hypothyroidism with hypoxia associated with CT features sugg...

Hypothesis: Exogenous kisspeptin-10 (Kp10) enhances pulsatile LH. Research strategy: A first-in-man dosing study of kp10 was first performed. Healthy volunteers and hypogonadal patients were subsequently infused with kp10. Dose titration study Rapid increases in LH with clear dose-dependency (P<0.0001) were observed in healthy men (n=6), with the 0.3 and 1 µg/kg doses being maximally stimulatory (P<0.01). Effect of sex-steroid milieu: LH respo...

LH hyper-secretion, driven by increased GnRH pulsatility, underpins excess testosterone secretion – a key clinical feature of PCOS.The kisspeptin-neurokinin B (NKB)-GnRH pathway has emerged as the pivotal regulator of reproduction. We hypothesised that pharmacologic blockade of NKB may address the central pathophysiology of LH hyper-secretion and hyperandrogenism in PCOS. We undertook a randomised, double blind, placebo-controlled multi-centre Phase...